Absorbed dose to man from the Se-75 labeled conjugated bile salt SeHCAT: concise communication

Journal Article · Mon Feb 01 04:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:5703097

Soundy, R G ^[1]; Simpson, J D; Ross, H M; Merrick, M V

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1. Amersham International Ltd., Bucks, England

The absorbed radiation dose that would result from the oral or intravenous administration of SeHCAT (23-(/sup 75/Se)selena-25-homotaurocholate) has been calculated using the MIRD tables and formulas and data from measurements of whole-body distribution and from long-term whole-body counting in rats, mice, and man. When SeHCAT is administered to normal subjects, the gallbladder is the critical organ, receiving 12 mrad (oral dose) or 22 mrad (i.v.) per microcurie. The whole-body dose is 1 mrad/..mu..Ci, whatever the route of administration. In severe hepatic failure the liver might receive 200 mrad/..mu..Ci. The activity likely to be used in routine clinical practice is 10 ..mu..Ci. Where a whole-body counter is used, an activity of 1 ..mu..Ci has proved adequate. Even at an administered activity of 25 ..mu..Ci, the absorbed dose is small compared with established techniques of investigating the gastrointestinal tract.

• OSTI ID: 5703097
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BILE ACIDS
BILIARY TRACT
BODY
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
DOSIMETRY
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
HYDROXY COMPOUNDS
INGESTION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MAN
MICE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIATION DOSES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SELENIUM 75
SELENIUM COMPOUNDS
SELENIUM ISOTOPES
STEROIDS
STEROLS
TISSUE DISTRIBUTION
VERTEBRATES