Comparison of isotope dilution mass spectrometry and graphite furnace atomic absorption spectrometry with Zeeman background correction for determination of plasma selenium

Journal Article · Thu May 01 04:00:00 EDT 1986 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00297a070· OSTI ID:5699662

Lewis, S A; Hardison, N W; Veillon, C

There has been increasing interest in the measurement of selenium in plasma because of the toxicological and nutritional importance of selenium. More recently selenium has been implicated as an anticarcinogen and a carcino-preventive agent. Several techniques are used to measure plasma selenium concentrations. One of the most popular, at present, is the use of graphite furnace atomic absorption spectrometry with Zeeman background correction (ZAAS), which permits the determination of selenium in plasma with minimal sample manipulation. Plasma is diluted with a matrix modifier containing Ni and Mg to thermally stabilize selenium and use a L'vov platform and peak area integration. However, this method is validated using an isotope dilution mass spectrometry (IDMS) technique, which can be considered a definitive method. Comparison of results obtained by two independent methods that utilize different physical properties is probably the best way to verify the accuracy of a new method. Imprecisions for both methods are established by the regular use of well-characterized reference materials. 7 references, 2 tables.

• Research Organization: Dept. of Agriculture, Beltsville, MD
• OSTI ID: 5699662
• Journal Information: Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 58:6; ISSN ANCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400104* -- Spectral Procedures-- (-1987)
ABSORPTION SPECTROSCOPY
ACCURACY
ALKALINE EARTH METALS
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
DATA
ELEMENTS
EXPERIMENTAL DATA
INFORMATION
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
MAGNESIUM
MASS SPECTROSCOPY
METALS
NICKEL
NUMERICAL DATA
PLASMA
QUANTITATIVE CHEMICAL ANALYSIS
SELENIUM
SEMIMETALS
SPECTROSCOPY
TRACER TECHNIQUES
TRANSITION ELEMENTS
ZEEMAN EFFECT