Nuclear magnetic resonance imaging of a fibrosarcoma tumor implanted in the rat

Journal Article · Fri Jul 01 04:00:00 EDT 1983 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.148.1.6856831· OSTI ID:5698599

Moon, K L; Davis, P L; Kaufman, L; Crooks, L E; Sheldon, P E; Miller, T; Brito, A C; Watts, J C

Fibrosarcoma tumor cells were implanted in the hind legs of 25 rats and studied from the first to the sixth week postimplantation. Nuclear magnetic resonance imaging detected all tumors and did not yield any false-positives in five control rats. The T1 relaxation values of tumors overlapped those of fat, but the combination of the two values allowed discrimination of each of the three tissues with no overlap. The difference in relaxation time between tumor and muscle could be accounted for on the basis of water content, which was approximtely 14% higher in the tumors. This study confirms data from previous studies suggesting that nuclear magnetic resonance imaging is a highly sensitive modality, but that T1 and T2 values are not specific for individual pathologic conditions.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5698599
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 148:1; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MODELS
BODY
BODY AREAS
DISEASES
EXPERIMENTAL NEOPLASMS
FIBROSARCOMAS
LEGS
LIMBS
MAGNETIC RESONANCE
MAMMALS
NEOPLASMS
NUCLEAR MAGNETIC RESONANCE
RATS
RESONANCE
RODENTS
SARCOMAS
TUMOR CELLS
VERTEBRATES