Decision model for biomarkers of exposure

Journal Article · Sat Nov 30 23:00:00 EST 1991 · Regulatory Toxicology and Pharmacology; (United States)

DOI:https://doi.org/10.1016/0273-2300(91)90031-P· OSTI ID:5696241

Stevens, D K; Bull, R J; Nauman, C H; Blancato, J N ^[1]

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1. College of Pharmacy, Washington State University, Pullman (United States)

The quantitation of exposure is one of the most critical elements of the risk assessment process. Contemporary risk assessment models rely on monitoring the target chemical in various environmental media and incorporate a variety of assumptions to estimate this. Recently, biomarkers have been advanced to improve estimates of the delivered dose of a given chemical or mixture of chemicals. A biomarker of exposure may be defined as an indicator of exposure to an environmental pollutant within the exposed organism, which becomes manifest before any adverse effects are evident. Measurement of such a biomarker within a biological system may potentially be used to identify and quantitate directly exposure to hazardous substances. This paper describes a decision model for the selection, evaluation, and validation of a biomarker of exposure.

• OSTI ID: 5696241
• Journal Information: Regulatory Toxicology and Pharmacology; (United States), Journal Name: Regulatory Toxicology and Pharmacology; (United States) Vol. 14:3; ISSN 0273-2300; ISSN RTOPD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MARKERS
DECISION MAKING
DOSE-RESPONSE RELATIONSHIPS
ENVIRONMENTAL EXPOSURE
MAMMALS
MAN
MATHEMATICAL MODELS
PRIMATES
RISK ASSESSMENT
VERTEBRATES
XENOBIOTICS