Biomarkers of exposure
- EPA, Las Vegas, NV (United States)
As the risk paradigm gains acceptance in the scientific community for setting priorities and choosing cost-effective mitigation strategies, increasing emphasis is being placed upon understanding multimedia/multiroute/multipathway exposures. The use of biomarkers offers great potential to integrate all routes, media, and pathways of exposure so that scientifically defensible risk characterizations can be realized. Together with environmental or exposure measurements and questionnaire/activity data, these may help to evaluate completeness of exposure assessments for all relevant media and pathways and to characterize {open_quotes}highly exposed{close_quotes} population groups. Biomarkers of exposure are indicators of current or historical contact with an environmental agent, including the agent itself or its metabolites, depending on the biological media and time-constants for metabolism, storage, and excretion of specific chemicals. This paper will review historical use of biomarkers of exposure and explore their potential for future research, assessment, and control of environmental risks.
- OSTI ID:
- 126055
- Report Number(s):
- CONF-950402--
- Country of Publication:
- United States
- Language:
- English
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