Comparative lung tumorigenicity of parent and mononitro-polynuclear aromatic hydrocarbons in the BLU:Ha newborn mouse assay
A BLU:Ha newborn mouse lung adenoma bioassay was employed to compare the tumorigenicity of selected mononitroarenes and unsubstituted parent compounds 6 months after initial treatment. The presence of a nitro group had a variable effect upon compound potency in which tumorigenicity was increased, abolished, or unchanged. On the basis of results with equimolar doses, the potency of benzo(a)pyrene was greater than 6-nitrobenzo(a)pyrene (inactive), 6-nitrochrysene was much greater than chrysene (inactive), 3-nitrofluoranthene (active) was equal to fluoranthene (active), and 1-nitropyrene (inactive) was equivalent to pyrene (inactive). The potency series among the mononitroarenes was 6-nitrochyrsene much greater than 3-nitrofluoranthene greater than 6-nitrobenzo(a)pyrene (inactive) = 1-nitropyrene (inactive). Lung tumor incidence and multiplicity were similar for both males and females. No consistent pattern was observed for the occasional appearance of lymphoma or hepatic nodular hyperplasia in the various treatment groups.
- Research Organization:
- Massachusetts Institute of Technology, Cambridge (USA)
- OSTI ID:
- 5696137
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Vol. 99:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay
Comparative effect of nitroarenes and their parent arenes on hepatic drug and carcinogen metabolism in rats
Related Subjects
BENZOPYRENE
CARCINOGEN SCREENING
CHRYSENE
FLUORENE
LUNGS
ADENOMAS
NITRO COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
PYRENE
CARCINOGENS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
METABOLIC ACTIVATION
MICE
NEONATES
STRUCTURE-ACTIVITY RELATIONSHIPS
TOXICITY
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
DISEASES
HYDROCARBONS
MAMMALS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SCREENING
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology