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Comparative lung tumorigenicity of parent and mononitro-polynuclear aromatic hydrocarbons in the BLU:Ha newborn mouse assay

Journal Article · · Toxicol. Appl. Pharmacol.; (United States)
; ; ; ;

A BLU:Ha newborn mouse lung adenoma bioassay was employed to compare the tumorigenicity of selected mononitroarenes and unsubstituted parent compounds 6 months after initial treatment. The presence of a nitro group had a variable effect upon compound potency in which tumorigenicity was increased, abolished, or unchanged. On the basis of results with equimolar doses, the potency of benzo(a)pyrene was greater than 6-nitrobenzo(a)pyrene (inactive), 6-nitrochrysene was much greater than chrysene (inactive), 3-nitrofluoranthene (active) was equal to fluoranthene (active), and 1-nitropyrene (inactive) was equivalent to pyrene (inactive). The potency series among the mononitroarenes was 6-nitrochyrsene much greater than 3-nitrofluoranthene greater than 6-nitrobenzo(a)pyrene (inactive) = 1-nitropyrene (inactive). Lung tumor incidence and multiplicity were similar for both males and females. No consistent pattern was observed for the occasional appearance of lymphoma or hepatic nodular hyperplasia in the various treatment groups.

Research Organization:
Massachusetts Institute of Technology, Cambridge (USA)
OSTI ID:
5696137
Journal Information:
Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 99:3; ISSN TXAPA
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ANIMALS
AROMATICS
BENZOPYRENE
BODY
CARCINOGEN SCREENING
CARCINOGENS
CHRYSENE
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
FLUORENE
HYDROCARBONS
LUNGS
MAMMALS
METABOLIC ACTIVATION
MICE
NEONATES
NEOPLASMS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
POLYCYCLIC AROMATIC HYDROCARBONS
PYRENE
RESPIRATORY SYSTEM
RODENTS
SCREENING
STRUCTURE-ACTIVITY RELATIONSHIPS
TOXICITY
VERTEBRATES