Regional blood flow during continuous low-dose endotoxin infusion

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Circ. Shock; (United States)

OSTI ID:5687800

Fish, R E; Lang, C H; Spitzer, J A

Escherichia coli endotoxin (ET) was administered to adult rats by continuous IV infusion from a subcutaneously implanted osmotic pump (Alzet). Cardiac output and regional blood flow were determined by the radiolabeled microsphere method after 6 and 30 hr of ET or saline infusion. Cardiac output (CO) of ET rats was not different from time-matched controls, whereas arterial pressure was 13% lower after 30 hr of infusion. After both 6 and 30 hr of ET, pancreatic blood flow and percentage of cardiac output were lower than in controls. Estimated portal venous flow was decreased at each time point, and an increased hepatic arterial flow (significant after 30 hr) resulted in an unchanged total hepatic blood flow. Blood flow to most other tissues, including epididymal fat, muscle, kidneys, adrenals, and gastrointestinal tract, was similar between treatments. Maintenance of blood flow to metabolically important tissues indicates that the previously reported alterations in in vitro cellular metabolism are not due to tissue hypoperfusion. Earlier observations of in vitro myocardial dysfunction, coexistent with the significant impairment in pancreatic flow, raise the possibility that release of a myocardial depressant factor occurs not only in profound shock but also under less severe conditions of sepsis and endotoxemia.

• Research Organization: Louisiana State Univ. Medical Center, New Orleans
• OSTI ID: 5687800
• Journal Information: Circ. Shock; (United States), Journal Name: Circ. Shock; (United States) Vol. 4; ISSN CRSHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ANTIGENS
BACTERIA
BLOOD CIRCULATION
BLOOD FLOW
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
ENDOCRINE GLANDS
ENDOTOXINS
ESCHERICHIA COLI
GLANDS
HEART
INFUSION
INTAKE
ISOTOPES
LIVER
MAMMALS
MATERIALS
MICROORGANISMS
MICROSPHERES
ORGANS
PANCREAS
PORTAL SYSTEM
RADIOISOTOPES
RATS
RODENTS
TISSUES
TOXIC MATERIALS
TOXINS
VEINS
VERTEBRATES