Mutagenic specificities of four stereoisomeric benzo(c)phenanthrene dihydrodiol epoxides

Journal Article · Wed Jan 01 04:00:00 EST 1992 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.89.1.368· OSTI ID:5687629

Bigger, C A.H.; John, J S; Dipple, A ^[1]; Yagi, Haruhiko; Jerina, D M ^[2]

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1. National Cancer Inst., Frederick, MD (United States)
2. National Inst. of Health, Bethesda, MD (United States)

The pS189 shuttle vector carrying a supF target gene was used to compare the mutagenic specificities of the four configurational isomers of benzo(c)phenanthrene 3,4-dihydrodiol 1,2-epoxide. One of these isomers is the most tumorigenic dihydrodiol epoxide tested to date and another is essentially inactive as a tumorigen. Overall mutagenicities were not correlated with tumorigenicities, but each configurational isomer induced a unique spectrum of mutational hot spots in the supF target gene, which monitors primarily point mutations. It is suggested that the demonstrated isomer-specific selectivity for mutation targets within the supF gene may be indicative of a similar selectivity for one gene versus another and that such selectivity may be one determinant of relative tumorigenicity.

• OSTI ID: 5687629
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 89:1; ISSN PNASA; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CONDENSED AROMATICS
DNA SEQUENCING
EMBRYONIC CELLS
EPOXIDES
GENE MUTATIONS
GENETIC EFFECTS
HYDROCARBONS
ISOMERS
KIDNEYS
MAMMALS
MAN
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHENANTHRENE
POLYCYCLIC AROMATIC HYDROCARBONS
PRIMATES
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES