Twenty-four hour radioactive iodine uptake in 35 patients with amiodarone associated thyrotoxicosis

Journal Article · Sun Dec 01 04:00:00 EST 1985 · J. Nucl. Med.; (United States)

OSTI ID:5678938

Martino, E; Aghini-Lombardi, F; Lippi, F; Baschieri, L; Safran, M; Braverman, L E; Pinchera, A

Amiodarone associated thyrotoxicosis (AAT) occurs in approximately 10% of patients treated with this iodine rich drug in areas of mild iodine deficiency. The thyroid radioactive iodine uptake (RAIU) is usually undetectable or very low in iodine-induced thyrotoxicosis. In the present study, 35 patients with AAT were evaluated. Twelve patients had no thyroid abnormalities by physical exam and all had 24-hr RAIU less than or equal to 4%. In contrast, nine of 11 patients with AAT and diffuse goiters and eight of 12 patients with AAT and nodular goiters had RAIU values greater than 8%. In patients with AAT and goiter it appears possible that the thyroid fails to adapt normally to the excess iodide load, resulting in an inappropriately high RAIU in the presence of excess plasma iodine.

• OSTI ID: 5678938
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BENZOFURANS
BODY
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
ETIOLOGY
FURANS
GLANDS
HETEROCYCLIC COMPOUNDS
HYPERTHYROIDISM
IODINE ISOTOPES
ISOTOPES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PATIENTS
RADIONUCLIDE KINETICS
THYROID
UPTAKE