Thyroid iodine content measured by x-ray fluorescence in amiodarone-induced thyrotoxicosis: concise communication

Journal Article · Fri Jul 01 04:00:00 EDT 1983 · J. Nucl. Med.; (United States)

OSTI ID:5601342

Leger, A F; Fragu, P; Rougier, P; Laurent, M F; Tubiana, M; Savole, J C

Iodine-induced thyrotoxicosis (IiT) is characterized by (a) a low radioiodine uptake, increased by exogenous TSH, and (b) a spontaneous evolution towards cure within a few months. An hypothetical pathogenesis of IiT is an initial inflation in the stores of thyroid hormones during iodine excess, followed by their sudden discharge into the circulation. Thyroid iodine content was measured by fluorescent scanning in 10 patients with amiodarone-induced thyrotoxicosis and in various control groups. Results were found to be high at the onset of the disease and to decrease during its course. The data agree with the hypothetical pathogenesis. Furthermore they may permit exclusion of a painless subacute thyroiditis, which is the main differential diagnosis of IiT.

• Research Organization: Institut Gustave Roussy, Villejuif, France
• OSTI ID: 5601342
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CHEMICAL ANALYSIS
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HYPERTHYROIDISM
NONDESTRUCTIVE ANALYSIS
ORGANS
PATHOGENESIS
PATIENTS
THYROID
X-RAY EMISSION ANALYSIS
X-RAY FLUORESCENCE ANALYSIS