Potentiation of radiation lethality in HeLa cells by mild hyperthermia and procaine
Journal Article
·
· Radiology; (United States)
- Mount Sinai Medical Center, New York
Increased radiation lethality was observed in HeLa cells when irradiation was followed by two hours of incubation at 41/sup o/C in the presence of 1 mM procaine hydrochloride. The increase of radiation lethality produced by this combination was significantly higher than that produced by hyperthermia alone. Two hours of incubation with procaine at 37/sup o/C had no effect on the survival of irradiation cells.
- OSTI ID:
- 5678015
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 141:2; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560201 -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HELA CELLS
HYPERTHERMIA
IRRADIATION
PROCAINE
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
TEMPERATURE DEPENDENCE
TEMPERATURE EFFECTS
560201 -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HELA CELLS
HYPERTHERMIA
IRRADIATION
PROCAINE
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
TEMPERATURE DEPENDENCE
TEMPERATURE EFFECTS