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Regeneration of hemopoietic precursor cells in spleen organ cultures from irradiated mice: influence of genotype of cells injected and of the spleen microenvironment

Journal Article · · Blood; (United States)
OSTI ID:5677586
;
The regeneration of hemopoietic precursor cells was monitored in spleen organ cultures from lethally irradiated mice injected with 10(7) normal syngeneic or allogeneic bone marrow cells. The important role of the microenvironment in supporting hemopoiesis was confirmed by the failure of mutant Sl/Sld spleens to support CFC regeneration in organ cultures. However, the extent and quality of the CFC regeneration was clearly dependent on the genetic properties of the injected cells. Evidence for this was obtained from the regeneration patterns of various CFC types in organ cultured spleens derived from different mouse donor-recipient strain combinations that maintained the differences in the bone marrow frequency of various CFC types characteristic of the donor strain.
Research Organization:
Walter and Eliza Hall Inst. of Medical Research, Victoria, Australia
OSTI ID:
5677586
Journal Information:
Blood; (United States), Journal Name: Blood; (United States) Vol. 57:5; ISSN BLOOA
Country of Publication:
United States
Language:
English

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Related Subjects

551000 -- Physiological Systems
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
BONE MARROW CELLS
CHIMERAS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
EXTERNAL IRRADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
IRRADIATION
MAMMALS
MICE
MOSAICISM
MUTATIONS
ORGANS
RADIATION CHIMERAS
RADIATION EFFECTS
RECOVERY
RODENTS
SOMATIC CELLS
SPLEEN
SPLEEN COLONY FORMATION
STEM CELLS
TISSUE CULTURES
VERTEBRATES