A survey of effects of gaseous and aerosol pollutants on pulmonary function of normal males

Journal Article · Tue Mar 01 04:00:00 EST 1983 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1983.10543989· OSTI ID:5669471

Stacey, R W ^[1]; Seal, E Jr; House, D E; Green, J; Roger, L J; Raggio, L

---

1. U.S. Environmental Protection Agency, Chapel Hill, NC

A total of 231 normal male human subjects were exposed for 4 hr to air, ozone, nitrogen dioxide, or sulfur dioxide; to sulfuric acid, ammonium bisulfate, ammonium sulfate, or ammonium nitrate aerosols; or to mixtures of these gaseous and aerosol pollutants. Only one concentration of each pollutant was used. This study, therefore, represents a preliminary survey, intended to allow direct comparison of studies to plan future research. During exposure each subject had two 15-min exercise sessions on a treadmill at 4 mph and 10% grade. Environmental conditions were mildly stressful, i.e., temperature = 30/sup 0/C and relative humidity = 60%. A battery of 19 measurements of pulmonary function was performed just prior to exposure (air control); 2 hr into the exposure, following the first exercise session; 4 hr into the exposure, following the second exercise session; and 24 hr after exposure, Significant differences were noted in specific air-way resistance (SRAW), forced vital capacity (FVC), and forced expiratory flow at 50% of FVC (FEF/sub 50/) and in related measurements in those experimental groups exposed to ozone or to ozone plus aerosols. None of the aerosols alone, nitrogen dioxide or sulfur dioxide alone, or mixtures of nitrogen dioxide or sulfur dioxide with aerosols produced significant effects. A distribution analysis of subject responsivity to ozone gave a normal distribution among subjects not exposed to ozone, and a distribution shifted to the right and skewed to the right among those exposed to ozone alone or in mixture, with no evidence of bimodal distribtion of ozone sensitivity.

• OSTI ID: 5669471
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 38:2; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMMONIUM COMPOUNDS
AMMONIUM NITRATES
AMMONIUM SULFATES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
CHALCOGENIDES
COLLOIDS
DISPERSIONS
EXERCISE
FUNCTIONS
HUMIDITY
HYDROGEN COMPOUNDS
INORGANIC ACIDS
LUNGS
NITRATES
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
POLLUTANTS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SOLS
SULFATES
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
SULFURIC ACID
TEMPERATURE EFFECTS