Oxygen effect and adaptation reactions of cells. Report 5. Limited use of Eh and pO/sub 2/ as quantitative indicators of modification of radiosensitivity
Journal Article
·
· Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5663016
In this work a quantitative analysis of tissue oxygen tension and redox potential, Eh, in relation to radiosensitivity modified by gas hypoxia and certain pharmacological agents was conducted. Male mice were exposed to total-body gamma radiation for the experiments. Oxygen tension was determined in subcutaneous tissue, bone marrow, and spleen by the polarographic method. Eh was measured by the electrometry method in subcutaneous tissue using standard methods with platinum electrodes. The radioprotective agents used were 2,3-aminopropylaminoethylthiophosphate and guanylthiourea.
- Research Organization:
- Oncological Research Center, Moscow, USSR
- OSTI ID:
- 5663016
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 19:1; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CARBONIC ACID DERIVATIVES
CRYOGENIC FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
ESTERS
FLUIDS
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MALES
MAMMALS
MICE
NONMETALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
REDOX POTENTIAL
RESPONSE MODIFYING FACTORS
RODENTS
SPLEEN
THIOPHOSPHORIC ACID ESTERS
THIOUREAS
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CARBONIC ACID DERIVATIVES
CRYOGENIC FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
ESTERS
FLUIDS
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MALES
MAMMALS
MICE
NONMETALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
REDOX POTENTIAL
RESPONSE MODIFYING FACTORS
RODENTS
SPLEEN
THIOPHOSPHORIC ACID ESTERS
THIOUREAS
TISSUES
VERTEBRATES