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Behavioral effects of chlorpromazine and diazepam combined with low-level microwaves. [Rats]

Journal Article · · Neurobehav. Toxicol.; (United States)
OSTI ID:5656978
; ;
Previous research findings on the interaction between drugs and microwave radiation were extended to chlorpromazine and to diazepam. The drugs were combined with a 1 mW/cm/sub 2/ pulsed microwave field (2.8 GHz) and effects were measured on a fixed interval (FI 1) schedule of food reinforcement with rats. Dose-effect functions with and without sham irradiation were established for each drug. At effective doses chlorpromazine consistently decreased rate of responding and reduced with-interval response patterning. Low to moderate doses of diazepam produced little change or increases in response rate, and higher doses produced a decline in response rate. Response patterning within intervals was reduced by increasing doses of diazepam. The animals were exposed to the microwave field alone before test sessions combining the drugs with microwave radiation. Microwave exposure alone did not affect FI performance. Microwave radiation in combination with either drug did not produce any alterations in the dose-effect functions.
Research Organization:
Naval Medical Research Institute, Bethesda, MD
OSTI ID:
5656978
Journal Information:
Neurobehav. Toxicol.; (United States), Journal Name: Neurobehav. Toxicol.; (United States) Vol. 2:2; ISSN NETOD
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560400 -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZINES
BEHAVIOR
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHLORPROMAZINE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
MAMMALS
MICROWAVE RADIATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTHIAZINES
PSYCHOTROPIC DRUGS
RADIATIONS
RATS
RODENTS
TRANQUILIZERS
VERTEBRATES