Cross-sectional study of a community with exceptional exposure to DDT
Journal Article
·
· JAMA, J. Am. Med. Assoc.; (United States)
The geometric mean level of total DDT in serum samples (76.2 ng/mL) from 499 persons living downstream from a defunct DDT-manufacturing plant was several times the national geometric mean (15.0 ng/mL). DDE isomers, metabolites of DDT, accounted for an average of 86.7% of total DDT. Total DDT levels increased with age, even when controlled for other independent variables also significantly associated with DDT: race, sex, fish consumption, years of residence, socioeconomic status, alcohol consumption, and serum triglyceride levels. Fish consumption, the second strongest determinant of DDT level, had one third the predictive power of age. Total DDT levels were not associated with specific illness or ill health. However, total DDT levels were positively associated with levels of serum cholesterol, triglyceride, and gamma-glutamyl transpeptidase. The finding that serum DDE levels increase with age suggests that no equilibrium in body burden has been reached or that pharmacokinetics or serum/adipose partition may vary with age.
- OSTI ID:
- 5656743
- Journal Information:
- JAMA, J. Am. Med. Assoc.; (United States), Journal Name: JAMA, J. Am. Med. Assoc.; (United States) Vol. 245:19; ISSN JAMAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
552000 -- Public Health
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AGE DEPENDENCE
ALCOHOLS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BLOOD SERUM
CHEMICAL PLANTS
CHOLESTEROL
DDT
ENVIRONMENTAL EXPOSURE PATHWAY
ENZYMES
ESTERS
ETHANOL
FISHES
HAZARDS
HEALTH HAZARDS
HYDROLASES
HYDROXY COMPOUNDS
INDUSTRIAL PLANTS
INSECTICIDES
LIPIDS
METABOLISM
METABOLITES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PEPTIDE HYDROLASES
PESTICIDES
SEX DEPENDENCE
STEROIDS
STEROLS
TRIGLYCERIDES
VERTEBRATES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AGE DEPENDENCE
ALCOHOLS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BLOOD SERUM
CHEMICAL PLANTS
CHOLESTEROL
DDT
ENVIRONMENTAL EXPOSURE PATHWAY
ENZYMES
ESTERS
ETHANOL
FISHES
HAZARDS
HEALTH HAZARDS
HYDROLASES
HYDROXY COMPOUNDS
INDUSTRIAL PLANTS
INSECTICIDES
LIPIDS
METABOLISM
METABOLITES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PEPTIDE HYDROLASES
PESTICIDES
SEX DEPENDENCE
STEROIDS
STEROLS
TRIGLYCERIDES
VERTEBRATES