Lethal, potentially lethal lesion model
A theoretical framework to describe the formation of lethal mutations by radiation is presented. Lesions that are repaired (and misrepaired) in each type of experiment described (delayed plating and split dose) are assumed to be the same. In this model the same (potentially lethal) lesions cause both sublethal and potentially lethal damage. Potentially lethal damage is defined as damage which may be modified by alterations in postirradiation conditions. Sublethal damage is cellular damage whose accumulation may lead to lethality. A crucial consideration in the expression of the damage is the kind of medium in which the cells are placed during the repair period. Fresh or growth medium (F-medium) is assumed to cause fixation of damage after about 3 hours, while no fixation (only misrepair) occurs in conditioned medium (C-medium).
- Research Organization:
- Lawrence Berkeley Lab., CA (USA)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 5652087
- Report Number(s):
- LBL-16549; CONF-830782-2; ON: DE84001325
- Resource Relation:
- Conference: 11. L. H. Gray conference on cellular repair of radiation damage - mechanisms and modifying agents, Glasgow, UK, 18 Jul 1983
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CELL KILLING
BIOLOGICAL RADIATION EFFECTS
LETHAL MUTATIONS
BIOLOGICAL MODELS
MATHEMATICAL MODELS
CHROMOSOMAL ABERRATIONS
DNA
LETHAL IRRADIATION
BIOLOGICAL EFFECTS
IRRADIATION
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
560121* - Radiation Effects on Cells- External Source- (-1987)