Lethal, potentially lethal lesion model
Conference
·
OSTI ID:5652087
A theoretical framework to describe the formation of lethal mutations by radiation is presented. Lesions that are repaired (and misrepaired) in each type of experiment described (delayed plating and split dose) are assumed to be the same. In this model the same (potentially lethal) lesions cause both sublethal and potentially lethal damage. Potentially lethal damage is defined as damage which may be modified by alterations in postirradiation conditions. Sublethal damage is cellular damage whose accumulation may lead to lethality. A crucial consideration in the expression of the damage is the kind of medium in which the cells are placed during the repair period. Fresh or growth medium (F-medium) is assumed to cause fixation of damage after about 3 hours, while no fixation (only misrepair) occurs in conditioned medium (C-medium).
- Research Organization:
- Lawrence Berkeley Lab., CA (USA)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 5652087
- Report Number(s):
- LBL-16549; CONF-830782-2; ON: DE84001325
- Country of Publication:
- United States
- Language:
- English
Similar Records
Chinese hamster V79 cells harbor potentially lethal damage which is neither fixed nor repaired for long times after attaining maximal survival under growth conditions
Factors influencing the repair of potentially lethal radiation damage in growth-inhibited human cells
The effect of postirradiation holding at 22[degrees]C on the repair of sublethal, potentially lethal and potentially neoplastic transforming damage in gamma-irradiated HeLa x skin fibroblast human hybrid cells
Journal Article
·
Tue Feb 28 23:00:00 EST 1995
· Radiation Research
·
OSTI ID:81192
Factors influencing the repair of potentially lethal radiation damage in growth-inhibited human cells
Journal Article
·
Wed Oct 31 23:00:00 EST 1973
· Radiat. Res., v. 56, no. 2, pp. 320-333
·
OSTI ID:4404778
The effect of postirradiation holding at 22[degrees]C on the repair of sublethal, potentially lethal and potentially neoplastic transforming damage in gamma-irradiated HeLa x skin fibroblast human hybrid cells
Journal Article
·
Mon Feb 28 23:00:00 EST 1994
· Radiation Research; (United States)
·
OSTI ID:6440613
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CHROMOSOMAL ABERRATIONS
DNA
IRRADIATION
LETHAL IRRADIATION
LETHAL MUTATIONS
MATHEMATICAL MODELS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CHROMOSOMAL ABERRATIONS
DNA
IRRADIATION
LETHAL IRRADIATION
LETHAL MUTATIONS
MATHEMATICAL MODELS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS