Tumor necrosis factor and interleukin 1 as mediators of endotoxin-induced beneficial effects

Journal Article · Tue Sep 01 04:00:00 EDT 1987 · Rev. Infect. Dis.; (United States)

DOI:https://doi.org/10.1093/clinids/9.Supplement_5.S607· OSTI ID:5650051

Urbaschek, R; Urbaschek, B

Bacterial lipopolysaccharides or endotoxins are known to induce tumor necrosis; enhanced nonspecific resistance to bacterial, viral, and parasitic infections and to radiation sickness; and tolerance to lethal doses of endotoxin. These beneficial effects are achieved by pretreatment with minute amounts of endotoxin. Recombinant tumor necrosis factor (TNF) and interleukin 1 (IL-1) are among the mediators capable of invoking radioprotection or resistance to the consequences of cecal ligation and puncture. Both cytokines are potent inducers of serum colony-stimulating factor (CSF) in C3H/HeJ mice (low responders to endotoxin). The number of splenic granulocyte-macrophage precursors was found to increase 5 days after injection of TNF in these mice. Although with IL-1 no increase in the number of granulocyte-macrophage colonies occurred in culture in the presence of serum CSF, a marked stimulation was observed when TNF was added. This stimulation of myelopoiesis observed in vivo and in vitro may be related to the radioprotective effect of TNF. The data presented suggest that TNF and IL-1 released after injection of endotoxin participate in the mediation of endotoxin-induced enhancement of nonspecific resistance and stimulation of hematopoiesis. 76 references.

• Research Organization: Univ. of Heidelberg, Germany, F.R.
• OSTI ID: 5650051
• Journal Information: Rev. Infect. Dis.; (United States), Journal Name: Rev. Infect. Dis.; (United States); ISSN RINDD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
ENDOTOXINS
GROWTH FACTORS
LYMPHOKINES
MACROPHAGES
MAMMALS
MATERIALS
MICE
MITOGENS
ORGANIC COMPOUNDS
PHAGOCYTES
PROTEINS
RADIATION PROTECTION
RADIOSENSITIVITY EFFECTS
RODENTS
SEPTICEMIA
SOMATIC CELLS
TOXIC MATERIALS
TOXINS
VERTEBRATES