Induction of proliferative and destructive graft-versus-host reactions in the small intestine

Journal Article · Wed Dec 31 23:00:00 EST 1986 · Adv. Exp. Med. Biol.; (United States)

DOI:https://doi.org/10.1007/978-1-4684-5344-7_77· OSTI ID:5649934

Felstein, M V; Mowat, A M

We have used the intestinal phase of a GvHR to investigate the immunological basis of enteropathies associated with CMI. The nature of the damage depends on the model of GvHR used. Adult unirradiated (CBAxBALB/cF1) mice with GvHR developed an entirely proliferative enteropathy characterized by crypt hyperplasia, increased numbers of IEL and enhanced NK cell activity, but there was no villus atrophy or CTL. Although neonatal or irradiated adult (CBAxBALB/c)F1 mice with GvHR developed a destructive enteropathy with marked villus atrophy and CTL activity, this also required an early proliferative phase identical to that found in unirradiated adult mice. Thus, we propose that proliferative enteropathy in GvHR is due to soluble mediators released by a local DTH reaction but that villus atrophy also requires activation of a further population of effector cells, which may be CTL or suppressor T cells.

• Research Organization: Univ. of Glasgow, Scotland, England
• OSTI ID: 5649934
• Journal Information: Adv. Exp. Med. Biol.; (United States), Journal Name: Adv. Exp. Med. Biol.; (United States) Vol. 216A; ISSN AEMBA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CHIMERAS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ENTERITIS
GASTROINTESTINAL TRACT
GRAFT-HOST REACTION
INTESTINES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MOSAICISM
ORGANS
RADIATION CHIMERAS
RODENTS
SMALL INTESTINE
SOMATIC CELLS
VERTEBRATES