Effects of exercise training on coronary transport capacity

Journal Article · Fri Feb 01 04:00:00 EST 1985 · J. Appl. Physiol.; (United States)

OSTI ID:5642801

Laughlin, M H

Coronary transport capacity was estimated in eight sedentary control and eight exercise-trained anesthetized dogs by determining the differences between base line and the highest coronary blood flow and permeability-surface area product (PS) obtained during maximal adenosine vasodilation with coronary perfusion pressure constant. The anterior descending branch of the left coronary artery was cannulated and pump- perfused under constant-pressure conditions (approximately equal to 100 Torr) while aortic, central venous, and coronary perfusion pressures, heart rate, electrocardiogram, and coronary flow were monitored. Myocardial extraction and PS of /sup 51/Cr-labeled ethylenediaminetetraacetic acid were determined with the single-injection indicator-diffusion method. The efficacy of the 16 +/- 1 wk exercise training program was shown by significant increases in the succinate dehydrogenase activities of the gastrocnemius, gluteus medialis, and long head of triceps brachii muscles. There were no differences between control and trained dogs for either resting coronary blood flow or PS. During maximal vasodilation with adenosine, the trained dogs had significantly lower perfusion pressures with constant flow and, with constant-pressure vasodilation, greater coronary blood flow and PS. It is concluded that exercise training in dogs induces an increased coronary transport capacity that includes increases in coronary blood flow capacity (26% of control) and capillary diffusion capacity (82% of control).

• Research Organization: Oral Roberts Univ. School of Medicine, Tulsa, OK
• OSTI ID: 5642801
• Journal Information: J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 58:2; ISSN JAPYA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADENOSINE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CHROMIUM 51
CHROMIUM ISOTOPES
CORONARIES
DOGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
ENZYME ACTIVITY
ENZYMES
EVEN-ODD NUCLEI
EXERCISE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PERFUSED ORGANS
PERMEABILITY
RADIOISOTOPES
RIBOSIDES
TRACER TECHNIQUES
VASODILATION
VERTEBRATES