Photohemolytic potency of tetracyclines
Hemolysis induced by long-wave ultraviolet radiation (UVA) and 8 different commercial tetracycline derivatives was studied in a model using human red blood cells. Demethylchlortetracycline and doxycycline were shown to have pronounced hemolytic properties causing 88% and 85% hemolysis, respectively, at a concentration of 50 micrograms/ml and 72 J/ cm2 of UVA. Tetracycline, oxytetracycline, and chlortetracycline caused maximally 18% hemolysis at 200 micrograms/ml and lymecycline only 7% at 100 micrograms/ml. Methacycline showed intermediate hemolytic effect of 36% at 200 micrograms/ml. Minocycline had no hemolytic effect whatsoever. These experimental data correlate very well with clinical reports and comparative phototoxicity trials in humans. Photohemolysis may thus be of value for predicting tetracycline phototoxicity.
- Research Organization:
- Lund Univ., Malmoe, Sweden
- OSTI ID:
- 5642428
- Journal Information:
- J. Invest. Dermatol.; (United States), Vol. 84:4
- Country of Publication:
- United States
- Language:
- English
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ERYTHROCYTES
BIOLOGICAL RADIATION EFFECTS
HEMOLYSIS
TETRACYCLINES
BIOLOGICAL EFFECTS
CHLORTETRACYCLINE
IN VITRO
MAN
PHOTOSENSITIVITY
ULTRAVIOLET RADIATION
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
LYSIS
MAMMALS
MATERIALS
PATHOLOGICAL CHANGES
PRIMATES
RADIATION EFFECTS
RADIATIONS
SENSITIVITY
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)