Dissociation of reticuloendothelial cell and hepatocyte functions in alcoholic liver disease: a clinical study with a new Tc-99m-labeled hepatobiliary agent

Journal Article · Wed Jul 01 00:00:00 EDT 1981 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198107000-00001· OSTI ID:5639044

Rao, B K; Weir, Jr, G J; Lieberman, L M

Tc-99m-sulfur colloid scintigrams were abnormal in four patients with hepatic dysfunction due to chronic alcohol abuse. Minimal uptake of radiocolloid in the liver suggested local reticuloendothelial (RE) cell failure. Imaging with a new hepatobiliary agent, Tc-99m-PIPIDA, revealed rapid hepatic accumulation and excretion of radiotracer with adequate visualization of the organ. Scintigraphic findings in these patients indicated a dissociation of hepatocyte and RE cell functions. Demonstration of adequate hepatocyte function with severe RE failure in alcoholic liver disease using a Tc-99m-labeled hepatobiliary agent has not been previously reported.

• OSTI ID: 5639044
• Journal Information: Clin. Nucl. Med.; (United States), Vol. 6:7
• Country of Publication: United States
• Language: English

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