Clinical comparison of /sup 99m/Tc-diethyl-IDA and /sup 99m/Tc-PIPIDA for evaluation of the hepatobiliary system

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Radiology; (United States)

OSTI ID:5253614

Klingensmith, W C; Fritzberg, A R; Spitzer, V M; Koep, L J

Fifteen patients with a wide range of hepatobiliary function were studied with both /sup 99m/Tc-diethyl-IDA and /sup 99m/Tc-PIPIDA. In images obtained 5 to 60 minutes after injection, /sup 99m/Tc-diethyl-IDA was clearly superior with respect to liver/background, hepatic ducts/liver, and small bowel/background ratios. The /sup 99m/Tc-diethyl-IDA transit time from blood to small intestine averaged 12.2 minutes less than that of /sup 99m/Tc-PIPIDA. Quantification of relative hepatocyte extraction efficiency indicated that it was 2.15 times higher for /sup 99m/Tc-diethyl-IDA. Cumulative 3-hour urine collections following injection demonstrated increasing renal excretion of /sup 99m/Tc-PIPIDA with rising total serum bilirubin levels in a manner quantitatively similar to that determined previously for /sup 99m/Tc-diethyl-IDA. The authors conclude that /sup 99m/Tc-diethyl-IDA is superior to /sup 99m/Tc-PIPIDA for studies of the hepatobiliary system.

• Research Organization: Univ. of Colorado, Denver
• OSTI ID: 5253614
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 134:1; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID ESTERS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
BILIRUBIN
BLOOD SERUM
BODY
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CLEARANCE
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
ESTERS
EXCRETION
EXPERIMENTAL DATA
GLANDS
GRAPHS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PIGMENTS
PYRROLES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RENAL CLEARANCE
SCINTISCANNING
TABLES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
YEARS LIVING RADIOISOTOPES