Tumor necrosis factor alpha selectively sensitizes human immunodeficiency virus-infected cells to heat and radiation
- Genentech, Inc., South San Francisco, CA (USA)
We report here that infection of the human T-cell line HUT-78 with human immunodeficiency virus (HIV) increases its sensitivity to heat and radiation toxicity. A possible explanation for this result may be the reduced expression of manganous superoxide dismutase (MnSOD) in HIV-infected cells compared to uninfected cells. Tumor necrosis factor alpha (TNF-alpha) further sensitizes HIV-infected cells but not uninfected cells to heat and radiation. This is consistent with the ability of TNF-alpha to induce the expression of MnSOD in uninfected but not in HIV-infected cells. HIV-infected HUT-78 cell lines engineered to overexpress MnSOD are more resistant to heat and radiation than HIV-infected cells that do not overexpress MnSOD. However, treatment with TNF-alpha still sensitizes these cells to heat and radiation.
- OSTI ID:
- 5638874
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 88:10; ISSN 0027-8424
- Country of Publication:
- United States
- Language:
- English
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