Effect of total lymphoid irradiation on levels of serum autoantibodies in systemic lupus erythematosus and in rheumatoid arthritis

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Arthritis Rheum.; (United States)

DOI:https://doi.org/10.1002/art.1780290104· OSTI ID:5633420

Tanay, A; Schiffman, G; Strober, S

The effects of total lymphoid irradiation (TLI) on serum levels of autoantibodies, and of antibodies to diphtheria toxoid, tetanus toxoid, and pneumococcal polysaccharide in patients with lupus nephritis were compared with those previously observed in rheumatoid arthritis (RA) patients. Baseline levels of antibodies to diphtheria toxoid and tetanus toxoid decreased significantly after TLI in patients with lupus and RA, but antibody levels to pneumococcal polysaccharide remained unchanged. After TLI, the levels of antinuclear and anti-DNA antibodies were reduced significantly in lupus, but levels of rheumatoid factor, antinuclear, and antigranulocyte antibodies all tended to increase in RA.

• Research Organization: Stanford Univ. Medical Center, CA
• OSTI ID: 5633420
• Journal Information: Arthritis Rheum.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
LUPUS
RADIOTHERAPY
LYMPHATIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
RHEUMATIC DISEASES
ANTIBODIES
INHIBITION
PATIENTS
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INFECTIOUS DISEASES
MEDICINE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
SKELETAL DISEASES
SKIN DISEASES
THERAPY
TUBERCULOSIS
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