On-line capillary electrophoresis with Fourier transform ion cyclotron resonance mass spectrometry

Journal Article · Wed Jul 28 04:00:00 EDT 1993 · Journal of the American Chemical Society; (United States)

DOI:https://doi.org/10.1021/ja00068a070· OSTI ID:5623618

Hofstadler, S A; Wahl, J H; Bruce, J E; Smith, R D ^[1]

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1. Pacific Northwest Lab., Richland, WA (United States)

The role of capillary electrophoresis (CE) in chemical and biochemical characterization is growing rapidly due to its speed, resolution, and flexibility for the manipulation of extremely small samples. CE was first combined with mass spectrometry (MS) at our laboratory. In this communication we report results for the first on-line combination of CE with Fourier transform ion cyclotron resonance (FTICR) mass spectrometry, an approach that is capable of providing both high CE and MS resolution and high sensitivity. The advantages of FTICR include the ability to simultaneously realize ultrahigh MS resolution/mass measurement accuracy and high sensitivity, as well as the capability for higher order tandem MS methods (i.e., MS[sup n], where n [ge] 2) for structural studies because of its nondestructive detection method. 20 refs., 3 figs.

• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5623618
• Journal Information: Journal of the American Chemical Society; (United States), Journal Name: Journal of the American Chemical Society; (United States) Vol. 115:15; ISSN JACSAT; ISSN 0002-7863
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
550200 -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
BLOOD VESSELS
BODY
CAPILLARIES
CARDIOVASCULAR SYSTEM
ELECTROPHORESIS
EVALUATION
LASERS
MASS SPECTROSCOPY
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
SPECTROSCOPY