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UCLA population studies of chronic obstructive respiratory disease. 9. Lung function changes associated with chronic exposure to photochemical oxidants; a cohort study among never-smokers

Journal Article · · Chest; (United States)
OSTI ID:5620264
; ; ; ; ; ;
Two cohorts of never-smoking residents of Los Angeles were studied on two occasions five years apart. One cohort (N = 1099) lived in a community with moderate levels of photochemical pollution and low levels of other pollutants, and the second (N = 1117) lived in a community with very high levels of photochemical oxidant and relatively high levels of sulfates and particulates. Studies included measurement of forced expiratory volumes and flow rates and single-breath nitrogen washout, as well as use of a standardized questionnaire. The data represent 47 percent of 2340 and 58 percent of 1935 residents, respectively, of the original community samples. Mean baseline spirometry and nitrogen washout for those who were and those who were not retested were similar, reflecting the fact that loss to follow-up was primarily due to changes of residence. In the more polluted area there were significantly worse lung function test results for both men and women at baseline and significantly more rapid deterioration at follow-up. Mean changes in nitrogen washout were significantly greater in the more polluted community for both sexes and for all age groups including children. Most of the spirometric test results showed significantly more rapid decline among adults in the more polluted community. These results are consistent with the hypothesis that chronic exposures to a mix of photochemical oxidants, sulfates and particulates are associated with increased loss of lung function, which is especially marked among tests that reflect function of the small airways.
Research Organization:
Univ. of California, Los Angeles
OSTI ID:
5620264
Journal Information:
Chest; (United States), Journal Name: Chest; (United States) Vol. 92:4; ISSN CHETB
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
AIR POLLUTION
BODY
CALIFORNIA
CHALCOGENIDES
CHRONIC EXPOSURE
DISEASES
DYNAMIC FUNCTION STUDIES
FEDERAL REGION IX
HAZARDS
HEALTH HAZARDS
LOS ANGELES
LUNGS
NORTH AMERICA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
PATHOGENESIS
PHOTOCHEMICAL OXIDANTS
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SULFATES
SULFUR COMPOUNDS
USA