The UCLA population studies of chronic obstructive respiratory disease. IV. Respiratory effect of long-term exposure to photochemical oxidants, nitrogen dioxide, and sulfates on current and never smokers

Journal Article · Tue Dec 01 04:00:00 EST 1981 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5498897

Detels, R; Sayre, J W; Coulson, A H; Rokaw, S N; Massey, Jr, F J; Tashkin, D P; Wu, M M

Questionnaires, spirometry, and the single-breath nitrogen test were administered to 3,192 participants 25 to 39 yr of age in area exposed to low concentrations of all pollutants (Lancaster, California) and to 2,369 similar participants living in an area exposed to high concentrations of photochemical oxidants, nitrogen dioxide, and sulfates (Glendora, California). The prevalence of symptoms and results in the majority of the tests were worse in the polluted area between current and never smokers and men and women. Those tests associated primarily with small airways (Vmax50, Vmax75, delta N 2(750-1250) showed little or no difference between areas. The difference in the prevalence of participants with a poor FEV1 and/or poor FEV1 and/or poor FVC and in the mean Vmax and closing volume was greater between areas than between smoking categories. These results suggest that long-term exposure to high concentrations of photochemical oxidants, NO2, and sulfates at place of residence may result in measurable impairment in both current smokers and never smokers. Firmer documentation of this effect will require following these populations for changes in lung function that correlate with pollutant exposures.

• Research Organization: School of Public Health, University of California, Los Angeles
• OSTI ID: 5498897
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 124:6; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
BODY
CALIFORNIA
CHALCOGENIDES
CHRONIC EXPOSURE
COLLOIDS
DISEASES
DISPERSIONS
DYNAMIC FUNCTION STUDIES
FEDERAL REGION IX
LOS ANGELES
LUNGS
MAMMALS
MAN
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NORTH AMERICA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHOTOCHEMICAL OXIDANTS
POLLUTION
PRIMATES
RESIDUES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SMOKES
SOLS
SULFATES
SULFUR COMPOUNDS
TOBACCO SMOKES
USA
VERTEBRATES