Effects of nitrogen dioxide on elastin and collagen contents of lung

Journal Article · Sun Jul 01 04:00:00 EDT 1979 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1979.10667404· OSTI ID:5615455

Kleinerman, J

Male Syrian hamsters were exposed to 30 +- 5 ppM nitrogen dioxide for 22 hr daily for 3 wk. Nitrogen dioxide-exposed hamsters sacrificed at various times during the 3 wk exposure showed a general loss of body weight and an increased dry lung weight when compared with the controls, which were housed in a similar, but nitrogen dioxide-free environment. Analysis of total lung collagen and total lung elastin revealed a net decrease in the moieties within 4 and 10 days, respectively, following commencement of nitrogen dioxide exposure. Total lung collagen returned toward pre-exposure levels by the 14th day of nitrogen dioxide exposure. Total lung elastin did not return toward normal until terminationn of nitrogen dioxide exposure. Recovery in room air for 3 wk following 21 days of nitrogen dioxide exposure restored the total pulmonary collagen and elastin to values similar to the control groups. These data suggest that the dynamics of elastin and collagen degradation and synthesis differ during and after nitrogen dioxide exposure. Lung collagen loss was observed earlier and was restored to normal values during the continuation of nitrogen dioxide exposure. Lung elastin loss occurred later and persisted during the entire period of exposure but returned to normal after exposure was terminated.

• Research Organization: Mt. Sinai Medical Center, New York, NY
• OSTI ID: 5615455
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 34:4; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOSYNTHESIS
BODY
CHALCOGENIDES
CHEMICAL REACTIONS
CHRONIC EXPOSURE
COLLAGEN
DECOMPOSITION
HAMSTERS
INHALATION
INTAKE
LUNGS
MALES
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PROTEINS
RECOVERY
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
SYNTHESIS
VERTEBRATES
WEIGHT