Selenium-sulfur analogs III: synthesis and biodistribution of two /sup 75/Se-labeled 4-substituted-1,2,3-selenadiazoles
Journal Article
·
· J. Pharm. Sci.; (United States)
The /sup 75/Se-labeled 4-substituted-1,2,3-selenadiazole analogs of two drugs that inhibit the adrenocorticosteroid 11 beta- and 17 alpha-hydroxylase enzymes were prepared by the (/sup 75/Se)selenious acid oxidation of the appropriate methyl ketone semicarbazones. The concentration of the radiolabeled compounds in the adrenal glands of rats over a 0.25--24-hr period was determined and compared with that in the blood, liver, and kidneys. The concentration in the adrenal glands and the target to nontarget ratios were much lower than those reported for other adrenocorticosteroid inhibitors. Therefore, these 1,2,3-selenadiazole agents do not have potential as adrenocorticosteroid imaging agents.
- OSTI ID:
- 5614549
- Journal Information:
- J. Pharm. Sci.; (United States), Journal Name: J. Pharm. Sci.; (United States) Vol. 70:1; ISSN JPMSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CHEMICAL PREPARATION
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DIAZO COMPOUNDS
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SELENIUM 75
SELENIUM ISOTOPES
SYNTHESIS
TISSUE DISTRIBUTION
USES
VERTEBRATES
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CHEMICAL PREPARATION
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DIAZO COMPOUNDS
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SELENIUM 75
SELENIUM ISOTOPES
SYNTHESIS
TISSUE DISTRIBUTION
USES
VERTEBRATES