Selenium-75--19-selenocholesterol: a new adrenal scanning agent with high concentration in the adrenal medulla
Journal Article
·
· J. Nucl. Med., v. 17, no. 3, pp. 212-217
OSTI ID:4038828
A tissue distribution study with $sup 75$Se-19-selenocholesterol in rats, rabbits, and dogs showed high adrenal concentrations and good adrenal images. In the dog, higher concentrations were obtained in the adrenal medulla than in the cortex at Days 1 and 7 after dosing. Extraction and thin-layer chromatography of the adrenal lipid in dogs given this compound showed that $sup 75$Se in the adrenal is still attached to the steroid moiety. A reduction in production costs is expected from its longer shelf life. Selenium-75-19- selenocholesterol is being evaluated in humans not only for routine use as an adrenal cortex scanning agent, but also for the detection of pheochromocytomas and other sympathetic tissue tumors, especially neuroblastomas. (auth)
- Research Organization:
- Univ. of Michigan Medical Center, Ann Arbor
- NSA Number:
- NSA-33-029853
- OSTI ID:
- 4038828
- Journal Information:
- J. Nucl. Med., v. 17, no. 3, pp. 212-217, Journal Name: J. Nucl. Med., v. 17, no. 3, pp. 212-217; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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