New and superior adrenal scanning agent, NP-59
The first synthesis of $sup 131$I-19-iodocholesterol had a 10 to 25 percent radiochemical impurity that was not iodide ion. This impurity has been identified as 6$beta$$-$$sup 131$I-iodomethyl-19-nor cholest-5(10)-en-3$beta$-ol (NP-59) and has been synthesized. Tissue distribution studies with $sup 131$I-NP- 59 in rats and dogs revealed a higher adrenal uptake and adrenal-to-tissue ratios compared to $sup 131$I 19-iodocholesterol, probably less in vivo deiodination, and superior adrenal images. A high uptake was seen in the adrenal medulla in addition to that in the cortex. Iodine-131-NP-59 is being evaluated for the early detection of adrenal--cortical disorders and as a potential scanning agent for detecting structural abnormalities of the adrenal medulla. (auth)
- Research Organization:
- Univ. of Michigan, Ann Arbor
- NSA Number:
- NSA-33-007630
- OSTI ID:
- 4160305
- Journal Information:
- J. Nucl. Med., v. 16, no. 11, pp. 1038-1042, Journal Name: J. Nucl. Med., v. 16, no. 11, pp. 1038-1042; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Adrenal gland imaging with multiplane tomography
Radiopharmaceuticals for diagnosis and treatment. Progress report, August 1, 1976--July 31, 1977. [/sup 125/I, /sup 131/I, /sup 75/Se, /sup 14/C, /sup 32/P]
Related Subjects
*RADIOPHARMACEUTICALS-- CHEMICAL PREPARATION
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
CHOLESTEROL
DOGS
IMPURITIES
IODINE 131
IODINE COMPOUNDS
LABELLED COMPOUNDS
N40420 --Chemistry--Radiochemistry & Nuclear Chemistry--Properties of Radioactive Materials
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
N48830 --Life Sciences--New Tracer Techniques--Other
RADIONUCLIDE KINETICS
RATS
TISSUE DISTRIBUTION