Age-related changes in bone in the dog: calcium homeostasis
Journal Article
·
· J. Orth. Res.; (United States)
To explore the changes in the relationship between skeletal and Ca/sup 2 +/ homeostasis with age, a study was made of 50 dogs divided into four age groups. The skeletal uptake of /sup 85/Sr decreased markedly with age, and the immunoreactive parathyroid hormone (iPTH) level increased. There was a significant correlation between iPTH value and the calculated short-term exchange of Ca in bone. Bone formation and bone resorption decreased with age except that in the oldest group of dogs the resorption increased. The authors suggest that in aging dogs the skeletal exchange of Ca falls to a very low level that decreases the immediate effect of PTH and thus leads to a chronic net increase in circulating PTH. Concomitant with this is an increase in osteoclastic bone resorption and, over a long time, loss of skeletal mass.
- Research Organization:
- Mayo Clinic, Rochester, MN
- OSTI ID:
- 5614245
- Journal Information:
- J. Orth. Res.; (United States), Journal Name: J. Orth. Res.; (United States) Vol. 2:1; ISSN JORED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CALCIUM
DAYS LIVING RADIOISOTOPES
DENSITY
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HOMEOSTASIS
HORMONES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
METALS
NUCLEI
ORGANS
PARATHORMONE
PEPTIDE HORMONES
PHYSICAL PROPERTIES
RADIOISOTOPES
SKELETON
STRONTIUM 85
STRONTIUM ISOTOPES
UPTAKE
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CALCIUM
DAYS LIVING RADIOISOTOPES
DENSITY
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HOMEOSTASIS
HORMONES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
METALS
NUCLEI
ORGANS
PARATHORMONE
PEPTIDE HORMONES
PHYSICAL PROPERTIES
RADIOISOTOPES
SKELETON
STRONTIUM 85
STRONTIUM ISOTOPES
UPTAKE
VERTEBRATES