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Radioimmunodetection of melanoma utilizing In-111 96. 5 monoclonal antibody: A preliminary report

Conference · · Radiology; (United States)
OSTI ID:5612418
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The murine 96.5 monoclonal antimelanoma antibody (MoAb) was labeled with In-111, and 1-20 mg were administered to 21 patients who had proved or suspected melanoma metastases. In four patients, unlabeled 96.5 MoAb was administered prior to the radiopharmaceutical. The scans were interpreted by two observers, one with full knowledge, the other with no knowledge of the cases. Increasing the MoAb mass or preinfusing unlabeled MoAb prior to the administration of In-111 MoAb resulted in a prolongation of In-111 MoAb of the serum half time, and appeared to improve tumor detection. In all patients who had metastatic disease, at least one tumor site was apparent. Fifty-six per cent of known lesions 1.5 cm or greater in size were detected by the physician who had knowledge of the cases when data from all doses were considered. Forty-nine per cent were detected by the other physician. The 96.5 In-111 MoAb appears to have utility for the detection of metastatic melanoma.
Research Organization:
Univ. of California, San Diego
OSTI ID:
5612418
Report Number(s):
CONF-851152-
Conference Information:
Journal Name: Radiology; (United States) Journal Volume: 155:2
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
HEAD
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MELANOMAS
METASTASES
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TISSUE DISTRIBUTION