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Neural, pituitary, and mammary tumors in Sprague-Dawley rats treated with X irradiation to the heat and N-ethyl-N-nitrosourea (ENU) during the early postnatal period: a statistical study of tumor incidence and survival

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576505· OSTI ID:5612082
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To study the late effects of early postnatal treatment with N-ethyl-N-nitrosourea (ENU) preceded by X irradiation to the heat, 226 neonatal CD rats were divided into six groups which received the following treatment: (1) 500-rad X irradiation to the head on the third postnatal day (pnd); (2) injection ip with 30 mg/kg ENU on the fourth pnd; (3) injection ip with 30 mg/kg ENU on the seventh pnd; (4) a combination of 500-rad X irradiation to the head on the third pnd, followed by ip 30 mg/kg ENU on the fourth pnd; (5) a combination of 500-rad X irradiation to the head on the third pnd, followed by ip 30 mg/kg ENU on the seventh pnd; and (6) untreated controls. The results indicate that (1) X irradiation to the head alone significantly extended the life span of females compared to that of control females, and did not affect survival of males; (2) X irradiation did not influence the latent period of mortality from neurogenic tumors when ENU was given 1 or 3 days afterward; (3) ENU itself was a factor in shortening latent period for mammary tumors; (4) X irradiation alone did not increase the incidence of mammary tumors, and revealed no protective effect on the ENU-induced mammary carcinogenesis; (5) X irradiation increased the prevalence of pituitary tumors in the females; (6) no enhancement of pituitary tumors by ENU was observed; and (7) there was a statistically significant association of pituitary and mammary tumors in females.

Research Organization:
Univ. of Cincinnati, OH
OSTI ID:
5612082
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 101:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BRAIN
CARCINOMAS
CENTRAL NERVOUS SYSTEM
DATA
DELAYED RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
EXPERIMENTAL DATA
GLANDS
HEAD
INFORMATION
IONIZING RADIATIONS
MAMMALS
MAMMARY GLANDS
MATHEMATICS
MORTALITY
NEONATES
NEOPLASMS
NERVOUS SYSTEM
NITROSO COMPOUNDS
NITROSOUREAS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PITUITARY GLAND
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
STATISTICS
VERTEBRATES
X RADIATION