Oncogenic response of rats with x-ray-induced microcephaly to transplacental ethylnitrosourea

Journal Article · Wed Dec 31 23:00:00 EST 1975 · J. Natl. Cancer Inst., v. 56, no. 1, pp. 59-64

OSTI ID:4015772

Warkany, J; Mandybur, T I; Kalter, H

The relation of congenital malformations to tumor development was examined. Pregnant Sprague-Dawley rats were given 200 rads of X-rays on the 15th or 16th day of gestation and injections of 10 mg ethylnitrosourea (ENU)/kg 1-4 days later, or they were irradiated or injected only. Surviving weanlings that had been irradiated had micrencephaly and other malformations. Offspring exposed to ENU only had no external deformities. By 15 months of age 16.7 percent of the offspring exposed to X-rays and ENU prenatally had developed neurogenic tumors, whereas 62.2 percent of those exposed to ENU alone had developed tumors. Those only irradiated had no tumors. Both of the former groups developed oligodendrogliomas, mixed gliomas, ependymomas, and schwannomas, but the first manifestations of tumors occurred later in the group receiving the combined treatment. This delay persisted during the subsequent period of the study. (auth)

• Research Organization: Univ. of Cincinnati Coll. of Medicine
• NSA Number: NSA-33-026264
• OSTI ID: 4015772
• Journal Information: J. Natl. Cancer Inst., v. 56, no. 1, pp. 59-64, Journal Name: J. Natl. Cancer Inst., v. 56, no. 1, pp. 59-64; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

*BRAIN-- NEOPLASMS
*MALFORMATIONS-- RADIOINDUCTION
*NEOPLASMS-- RADIOINDUCTION
*NERVOUS SYSTEM-- NEOPLASMS
*NITROSO COMPOUNDS-- BIOLOGICAL EFFECTS
*UREA-- BIOLOGICAL EFFECTS
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
BIOLOGICAL RADIATION EFFECTS
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PRENATAL IRRADIATION
PROGENY
RATS
X RADIATION