Controlled long-term release of small peptide hormones using a new microporous polypropylene polymer: its application for vasopressin in the Brattleboro rat and potential perinatal use

Journal Article · Sat Dec 01 00:00:00 EST 1984 · J. Pharm. Sci.; (United States)

DOI:https://doi.org/10.1002/jps.2600731213· OSTI ID:5611905

Kruisbrink, J; Boer, G J

Based on drug release by microporous hollow fibers and the recent introduction of microporous polymers, a new technique was developed for controlled delivery of peptides. Small-diameter microporous polypropylene tubing, lumen-loaded with microgram quantities of vasopressin, and coated with collodion, releases vasopressin after in vitro immersion slowly (1-100 ng/d) and constantly for months. The mechanism of pseudo-zero-order delivery is based on high adsorption of vasopressin, keeping the void volume concentration of dissolved vasopressin constant, which is consequently a constant driving force of outward diffusion. The collodion coating prevents the entry of proteinaceous compounds which would result in rapid desorption of vasopressin. The present delivery module provides a lasting release for other peptides as well (lysine-vasopressin, oxytocin, alpha-melanocyte-stimulating hormone and, to a lesser extent, Met-enkephalin). The microporous polymer-collodion device is biocompatible and, loaded with vasopressin, successfully alleviates the diabetes insipidus of Brattleboro rats deficient for vasopressin. Subcutaneous implantation normalized diuresis for a period of 60 d and constant urine vasopressin excretion is observed. When the commercially available osmotic minipump is too large for implantation, the small size of the present controlled-delivery system allows peptide treatment of young and immature laboratory rats, even if located in utero.

• Research Organization: The Netherlands Institute for Brain Research, Amsterdam
• OSTI ID: 5611905
• Journal Information: J. Pharm. Sci.; (United States), Vol. 73:12
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IMPLANTS
EVALUATION
VASOPRESSIN
INJECTION
EXCRETION
IODINE ISOTOPES
RATS
TIME DEPENDENCE
TRACER TECHNIQUES
ANIMALS
CLEARANCE
HORMONES
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
PEPTIDE HORMONES
PITUITARY HORMONES
RODENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics