Effects of therapeutic radiation on microstructure of the human mandible
Journal Article
·
· Am. J. Anat.; (United States)
Mandibular bone from eight patients who had received therapeutic radiation (6000 to 7200 rads) for intra-oral cancer was obtained at surgery (1 month to 9 years after radiation) and compared histologically with non-irradiated mandibular bone from five subjects. Measurements made on the internal remodeling process of cortical bone included the extent of internal surface and the fraction indicating resorption, and the proportions of osteones which were incomplete (less than 3/4 filled with matrix), complete, and plugged. Appreciable differences were observed in all parameters except plugged osteones. The findings suggested early cessation of osteogenesis, and somewhat later cessation of resorption, without subsequent resumption of either process. The histologic appearance of the osteoblasts, osteoclasts, and osteones was in accord. Microfractures found in the irradiated bone were not seen to have healed. Radiation damage to the osteoprogenitor cells is postulated.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 5610357
- Journal Information:
- Am. J. Anat.; (United States), Journal Name: Am. J. Anat.; (United States) Vol. 151:2; ISSN AJANA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BONE FRACTURES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASES
EXTERNAL IRRADIATION
HEALING
INJURIES
IRRADIATION
JAW
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RECOVERY
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
SKULL
SOMATIC CELLS
THERAPY
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BONE FRACTURES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASES
EXTERNAL IRRADIATION
HEALING
INJURIES
IRRADIATION
JAW
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RECOVERY
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
SKULL
SOMATIC CELLS
THERAPY