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Expression of a multidrug-resistance gene in human tumors and tissues

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
; ; ; ; ;
The identification and cloning of a segment of a human multidrug resistance gene (mdr1) was reported recently. To examine, the molecular basis of one type of multidrug resistance, the authors have prepared RNA from human tumors and normal tissues and measured their content of mdr1 RNA. They find that the mdr1 gene is expressed at a very high level in the adrenal gland; at a high level in the kidney; at intermediate levels in the lung, liver, lower jejunum, colon, and rectum; and at low levels in many other tissues. The mdr1 gene is also expressed in several human tumors, including many but not all tumors derived from the adrenal gland and the colon. In addition, increased expression was detected in a few tumors at the time of relapse following initial chemotherapy. Although controlled clinical studies will be required, the results suggest that measurement of mdr1 RNA may prove to be a valuable tool in the design of chemotherapy protocols.
Research Organization:
National Institutes of Health, Bethesda, MD
OSTI ID:
5607131
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:1; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL GLANDS
ALKALOIDS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AROMATICS
AZAARENES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
CLONING
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DNA
DNA-CLONING
DOXORUBICIN
DRUGS
ELECTROPHORESIS
ENDOCRINE GLANDS
GASTROINTESTINAL TRACT
GENE REGULATION
GLANDS
HETEROCYCLIC COMPOUNDS
HYBRIDIZATION
INDOLES
INTESTINES
ISOTOPES
KIDNEYS
LIGHT NUCLEI
LIVER
MAMMALS
MAN
MESSENGER-RNA
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PRIMATES
PYRROLES
RADIOISOTOPES
RECOMBINANT DNA
RNA
SENSITIVITY
SKIN
THERAPY
VERTEBRATES
VINBLASTINE