Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.2.695· OSTI ID:5052260

Cordon-Cardo, C; O'Brien, J P; Casals, D; Biedler, J L; Melamed, M R; Bertino, J R ^[1]; Rittman-Grauer, L ^[2]

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1. Memorial Sloan-Kettering Cancer Center, New York, NY (USA)
2. Hybritech, Inc., San Diego, CA (USA)

Endothelial cells of human capillary blood vessels at the blood-brain and other blood-tissue barrier sites express P-glycoprotein as detected by mouse monoclonal antibodies against the human multidrug-resistance gene product. This pattern of endothelial cell expression may indicate a physiological role for P-glycoprotein in regulating the entry of certain molecules into the central nervous system and other anatomic compartments, such as the testes. These tissues, which limit the access of systemic drugs, are known pharmacologic sanctuaries for metastatic cancer. P-glycoprotein expression in capillary endothelium of brain and testes and not other tissues (i.e., kidney and placenta) may in part explain this phenomenon and could have important implications in cancer chemotherapy.

• OSTI ID: 5052260
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 86:2; ISSN PNASA; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ANTIBODIES
BIOCHEMISTRY
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CHEMOTHERAPY
CYTOCHEMISTRY
ENDOTHELIUM
GENE REGULATION
GLYCOPROTEINS
GONADS
MALE GENITALS
MAMMALS
MAN
MONOCLONAL ANTIBODIES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
SENSITIVITY
SKIN
TESTES
THERAPY
TISSUES
VERTEBRATES