Management of stage II Hodgkin's disease with a large mediastinal mass: a prospective program emphasizing irradiation

Journal Article · Fri Feb 01 04:00:00 EST 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90157-9· OSTI ID:5606164

Hoppe, R T

Between October 1980 and July 1983, 13 patients with clinical Stage II Hodgkin's disease who had a large mediastinal mass were entered into a prospective treatment program emphasizing irradiation. Careful clinical staging, including CT scanning, was completed in order to define precisely the extent of disease in the chest. The range of MMR was .34 to .56. By the time mantle irradiation was completed the MMR ranged from .21 to .35. Twelve patients underwent laparotomy after adequate reduction of the mediastinal mass size, but only two had subdiaphgragmatic disease detected. One patient had disease extension into the lung during mantle irradiation and one patient failed in a rib six months after completion of irradiation. Both have been treated successfully with salvage chemotherapy. All the remaining patients received prophylactic irradiation below the diaphragm and all are doing well with a median follow up of 21 months. The 2 year actuarial freedom from relapse of the entire group of 13 patients is 83%. These early results are very encouraging for this unfavorable group of patients with large mediastinal masses. Careful monitoring of tumor response and use of a shrinking field technique has helped to keep complications to a minimum.

• Research Organization: Stanford Univ. School of Medicine, CA
• OSTI ID: 5606164
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHEMOTHERAPY
CHEST
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EXTERNAL IRRADIATION
FIBROSIS
HERPES ZOSTER
HODGKINS DISEASE
INFECTIOUS DISEASES
IRRADIATION
LUNGS
LYMPHOMAS
MEDIASTINUM
MEDICINE
NEOPLASMS
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
PNEUMONITIS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TOMOGRAPHY
VIRAL DISEASES