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Irradiation in the treatment of Hodgkin's disease: a follow-up report

Journal Article · · Radiology; (United States)
OSTI ID:5920924
;
From 1971 through 1976, 167 patients with Hodgkin's disease received radiation therapy. In 132, staging was determined upon laparotomy; the others had clinical staging. Most patients with stage I or II disease received either mantle or para-aortic-iliac irradiation, while the others received more extensive irradiation with or without chemotherapy. Overall five-year actuarial survival rate was 87%; Stage I, 97%; Stage II, 85%; and Stage III, 82%. Fifty-nine of the 167 patients had relapse of disease, and most relapses were seen in Stage II, located in the nodal sites on the opposite side of the diaphragm. Overall five-year relapse-free survival was 58%; Stage I, 94%; Stage II, 43%; and Stage III, 59%. Survival after the first relapse was 69%. Based on their results, the authors feel that Stage I disease of supradiaphragmatic presentation can be treated effectively with mantle field irradiation alone. In treating Stage II disease, mantle field irradiation alone was not optimal, and the authors recommend subtotal nodal irradiation.
Research Organization:
Univ. of Michigan, Ann Arbor
OSTI ID:
5920924
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 139:2; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
DISEASES
DRUGS
HODGKINS DISEASE
IRRADIATION
LOCAL IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ONCOVIN
ORGANIC COMPOUNDS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY