Technetium-99m radiochemical assay by rapid filtration: A superior alternative to chromatography

Journal Article · Thu Jun 01 00:00:00 EDT 1989 · Journal of Pharmaceutical Sciences; (USA)

DOI:https://doi.org/10.1002/jps.2600780615· OSTI ID:5605762

Coupal, J J ^[1]

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1. Veterans Administration Medical Center, Lexington, KY (USA)

A new method for simultaneously measuring radiochemical purity and estimated lung trapping of colloidal technetium-99m ({sup 99m}Tc) radiopharmaceuticals is described. The method employs a small filtration device comprised of two stacked membrane filters, differing in membrane composition and in pore size, situated over a filtrate collection vial. Specifically, an 8-microns pore polycarbonate membrane filter is situated above a 0.22-microns pore mixed-cellulose-esters membrane filter. For assay, a diluted aliquot of radiopharmaceutical is passed through the filtration device. Technetium-99m radioactivity on the membranes and in the vial is then measured. The polycarbonate filter traps and quantitates lung-capillary-occluding particles. The mixed-cellulose-esters filter traps and quantitates radiocolloid particles irrespective of relative size. The filtrate contains free pertechnetate. Within 4 min, this method yields results that compare well with those achieved by conventional techniques. The method works equally well for large colloidal particles (({sup 99m}Tc)stannous colloid), intermediate-size particles (({sup 99m}Tc)sulfur colloid), and small-size particles (({sup 99m}Tc) antimony trisulfide colloid).

• OSTI ID: 5605762
• Journal Information: Journal of Pharmaceutical Sciences; (USA), Journal Name: Journal of Pharmaceutical Sciences; (USA) Vol. 78:6; ISSN JPMSA; ISSN 0022-3549
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHROMATOGRAPHY
COLLOIDS
DISPERSIONS
DRUGS
FILTRATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
PARTICLE SIZE
RADIOASSAY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SIZE
TECHNETIUM 99
TECHNETIUM ISOTOPES
THIN-LAYER CHROMATOGRAPHY
YEARS LIVING RADIOISOTOPES