Estrogen receptor-mediated cytotoxicity using iodine-125

Journal Article · Sat Jan 01 04:00:00 EST 1983 · J. Cell. Biochem.; (United States)

DOI:https://doi.org/10.1002/jcb.240210106· OSTI ID:5605035

Bloomer, W D; McLaughlin, W H; Milius, R A; Weichselbaum, R R; Adelstein, S J

Auger effects from /sup 125/I decay are singularly damaging if localized in DNA as the thymidine analogue /sup 125/I-iododeoxyuridine (/sup 125/IUdR). Recent experience with steroid sex hormones extends these observations by demonstrating cytotoxicity in sites other than the DNA backbone. We have compared the cytotoxicity in human MCF-7 breast cancer cells of /sup 125/IUdR, /sup 125/I-iodotamoxifen, a nonsteroidal antiestrogen that is translocated from the cytoplasm to the nucleus of receptor containing cells, and /sup 125/I-iodoantipyrine, a biological indicator of the body water space. Cytotoxicity is critically dependent upon subcellular localization.

• Research Organization: Department of Radiation Therapy, Harvard Medical School, Boston, Massachusetts
• OSTI ID: 5605035
• Journal Information: J. Cell. Biochem.; (United States), Journal Name: J. Cell. Biochem.; (United States) Vol. 21:1; ISSN JCEBD
• Country of Publication: United States
• Language: English

Related Subjects

560122* -- Radiation Effects on Cells-- Internal Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIPYRETICS
ANTIPYRINE
AZOLES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CULTURES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DAYS LIVING RADIOISOTOPES
DNA
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTROGENS
GLANDS
HETEROCYCLIC COMPOUNDS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMARY GLANDS
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRAZOLES
PYRAZOLINES
RADIATION EFFECTS
RADIOISOTOPES
RECEPTORS
STEROID HORMONES
TRACER TECHNIQUES
TUMOR CELLS