Teratogenic, biochemical, and histological studies with mice prenatally exposed to 2. 45-GHz microwave radiation
Pregnant CD-1 mice were exposed to 2.45-GHz continuous wave microwave radiation at an incident power density of 30 mW/Cm/sup 2/. The local specific absorption rate near the uterine area (deep colonic location), as determined from time-temperature profiles measured with a Vitek thermistor probe, was 40.2 mW/G. Groups of mice were exposed 8 hr per day through Days 1-6 or 6-15 of pregnancy. Other groups of animals were exposed to an elevated ambient temperature of 31/sup 0/C which increased the colonic temperature 2.3/sup 0/C, the same as that produced by the microwaves. For the two conditions, temperature exposed and sham exposed, two groups of animals were used. One group was handled in the same manner as the microwave-irradiated group and the other group was not handled so as to evaluate the effects of stressing the animals by handling. On Day 18 of gestation the dams of all experimental groups were sacrificed and their reproductive status was determined. The fetuses were examined for visceral and skeletal alterations. Brain cholinesterase activity and histology were evaluated in the groups exposed on Days 6-15. The results show that microwave radiation increases embryo lethality at the early stages of gestation. Fetal toxicity and teratogenicity were not significantly increased by exposure to microwaves on either Days 1-6 or 6-15 of gestation. Cholinesterase activity and histology of the brain of 18-day-old fetuses were not adversely affected.
- Research Organization:
- National Institute of Environmental Health Sciences, Research Triangle Park, NC
- OSTI ID:
- 5602860
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 102:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOXYLESTERASES
CHOLINESTERASE
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
ESTERASES
FREQUENCY RANGE
GHZ RANGE
GHZ RANGE 01-100
HISTOLOGY
HYDROLASES
MAMMALS
MICE
MICROWAVE RADIATION
ORGANS
PRENATAL EXPOSURE
RADIATIONS
RODENTS
SKELETON
TEMPERATURE EFFECTS
TERATOGENESIS
VERTEBRATES