Milan hypertensive rat as a model for studying cation transport abnormality in genetic hypertension
Environmental factors, genetic polymorphisms, and different experimental designs have been the main impediments to evaluating a genetic association between cell membrane cation transport abnormalities and human essential or genetic hypertension. We review the results obtained in the Milan hypertensive strain of rats (MHS) and in its appropriate control normotensive strain (MNS) to illustrate our approach to defining the role of cation transport abnormality in a type of genetic hypertension. Before the development of a difference in blood pressure between the two strains, the comparison of kidney and erythrocyte functions showed that MHS had an increased glomerular filtration rate and urinary output, and lower plasma renin and urine osmolality. Kidney cross-transplantation between the strains showed that hypertension is transplanted with the kidney. Proximal tubular cell volume and sodium content were lower in MHS while sodium transport across the brush border membrane vesicles of MHS was faster. Erythrocytes in MHS were smaller and had lower sodium concentration, and Na+-K+ cotransport and passive permeability were faster. The differences in volume, sodium content, and Na+-K+ cotransport between erythrocytes of the two strains persisted after transplantation of bone marrow to irradiated F1 (MHS X MNS) hybrids. Moreover, in normal segregating F2 hybrid populations there was a positive correlation between blood pressure and Na+-K+ cotransport. These results suggest a genetic and functional link in MHS between cell membrane cation transport abnormalities and hypertension. Thus, erythrocyte cell membrane may be used for approaching the problem of defining the genetically determined molecular mechanism underlying the development of a type of essential hypertension. 35 references.
- Research Organization:
- Istituto Ricerche Farmitalia Carlo Erba, Nerviano, Italy
- OSTI ID:
- 5602464
- Journal Information:
- Hypertension (Dallas); (United States), Vol. 10
- Country of Publication:
- United States
- Language:
- English
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CELL MEMBRANES
PERMEABILITY
HYPERTENSION
PATHOGENESIS
POTASSIUM
MEMBRANE TRANSPORT
SODIUM
BIOLOGICAL MODELS
BLOOD PRESSURE
BONE MARROW
CATIONS
ERYTHROCYTES
IRRADIATION
KIDNEYS
PHENOTYPE
RADIATION CHIMERAS
RATS
TRANSPLANTS
ALKALI METALS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CELL CONSTITUENTS
CHARGED PARTICLES
CHIMERAS
DISEASES
ELEMENTS
HEMATOPOIETIC SYSTEM
IONS
MAMMALS
MATERIALS
MEMBRANES
METALS
MOSAICISM
ORGANS
RODENTS
SYMPTOMS
TISSUES
VASCULAR DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals