Reduced sodium concentration and increased sodium-potassium pump activity of erythrocytes in human hypertension
Journal Article
·
· Hypertension (Dallas); (United States)
Erythrocyte Nai, Nai/Ki and ouabain-sensitive and ouabain-insensitive /sup 86/Rb uptake (K transport) were measured in whole blood of 16 normotensive and 19 hypertensive white male subjects, within seconds or minutes after withdrawal of blood. Erythrocyte Nai and Nai/Ki were reduced (p less than 0.05), and ouabain-sensitive /sup 86/Rb uptake was increased (p less than 0.01) in hypertensive subjects. In a separate group of hypertensive white male subjects, an inverse correlation was found between erythrocyte Nai/Ki and ouabain-binding sites per erythrocyte (r = 0.85, p less than 0.01, n = 9). The abnormalities of erythrocyte cation fluxes in hypertensive subjects are similar to those induced by aldosterone in vascular smooth muscle cells and by glucocorticoid administration in the erythrocytes of human subjects, suggesting similarities in pathogenesis.
- Research Organization:
- Veterans Administration Medical Center, Minneapolis, MN
- OSTI ID:
- 6071626
- Journal Information:
- Hypertension (Dallas); (United States), Journal Name: Hypertension (Dallas); (United States) Vol. 9; ISSN HPRTD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Erythrocyte sodium concentration and sup 86 Rb uptake in weanling Dahl rats
Effect of hypertensive rat plasma on ion transport of cultured vascular smooth muscle
Racial differences in red cell cation transport and their relationship to essential hypertension
Journal Article
·
Tue Aug 01 00:00:00 EDT 1989
· American Journal of Hypertension; (USA)
·
OSTI ID:5359273
Effect of hypertensive rat plasma on ion transport of cultured vascular smooth muscle
Journal Article
·
Fri Oct 31 23:00:00 EST 1986
· Am. J. Physiol.; (United States)
·
OSTI ID:6915075
Racial differences in red cell cation transport and their relationship to essential hypertension
Journal Article
·
Wed Dec 31 23:00:00 EST 1980
· Clin. Exp. Hypertens.; (United States)
·
OSTI ID:5467221
Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL ISOTOPES
ALKALI METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CATIONS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELEMENTS
ERYTHROCYTES
GLYCOSIDES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
MATERIALS
MEMBRANE PROTEINS
MEMBRANE TRANSPORT
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OUABAIN
PATHOGENESIS
POTASSIUM
PRIMATES
PROTEINS
RADIOISOTOPES
RECEPTORS
RUBIDIUM 86
RUBIDIUM ISOTOPES
SODIUM
STROPHANTHINS
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL ISOTOPES
ALKALI METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CATIONS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELEMENTS
ERYTHROCYTES
GLYCOSIDES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
MATERIALS
MEMBRANE PROTEINS
MEMBRANE TRANSPORT
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OUABAIN
PATHOGENESIS
POTASSIUM
PRIMATES
PROTEINS
RADIOISOTOPES
RECEPTORS
RUBIDIUM 86
RUBIDIUM ISOTOPES
SODIUM
STROPHANTHINS
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES