Preliminary studies on the spatial-temporal microdistribution of inhaled soluble plutonium in the lungs of dogs
Conference
·
· Proc. Soc. Exp. Biol. Med.; (United States)
OSTI ID:5601901
The pulmonary microdistribution of inhaled soluble plutonium in four beagle dogs was studied in autoradiographs of histologic sections and transmission electron micrographs of lungs. Dogs were exposed to a single nose-only aerosol of /sup 239/Pu nitrate with a post-exposure time ranging from 1 month to 42 months. At one month after the exposure, the plutonium was dispersed throughout the lung section, with a higher percentage of the activity found on alveolar macrophages and alveolar septa. However, a nonrandom localization of the plutonium was observed as time passed. The focal concentrations were primarily in nodular or diffuse interstitial fibrotic tissues typically contiguous with subpleural, peribronchial, or perivascular areas. More than 50% of the total activity was in the form of single-tracks at one month exposure, and this percentage increased with time. In summary, this preliminary study suggests an initial random dispersion of soluble plutonium with increased concentration of activity to nonrandom focal locations with time.
- Research Organization:
- Whitman College, Walla Walla, WA
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 5601901
- Report Number(s):
- CONF-8610350-
- Conference Information:
- Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Journal Volume: 185:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Microdistribution and Long-Term Retention of 239Pu (NO3)4 in the Respiratory Tracts of an Acutely Exposed Plutonium Worker and Experimental Beagle Dogs
Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs.
Primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide
Journal Article
·
Thu Nov 01 00:00:00 EDT 2012
· Cancer Research, 72(21):5529-5536
·
OSTI ID:1057822
Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs.
Journal Article
·
Tue Dec 31 23:00:00 EST 2013
· International Journal of Radiation Biology
·
OSTI ID:1130217
Primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide
Journal Article
·
Sat Oct 31 23:00:00 EST 1987
· Radiat. Res.; (United States)
·
OSTI ID:5719536
Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ACUTE EXPOSURE
ALPHA DECAY RADIOISOTOPES
BODY
DISTRIBUTION
EVEN-ODD NUCLEI
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNGS
NUCLEI
ORGANS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
TIME DEPENDENCE
TISSUE DISTRIBUTION
YEARS LIVING RADIOISOTOPES
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ACUTE EXPOSURE
ALPHA DECAY RADIOISOTOPES
BODY
DISTRIBUTION
EVEN-ODD NUCLEI
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNGS
NUCLEI
ORGANS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
TIME DEPENDENCE
TISSUE DISTRIBUTION
YEARS LIVING RADIOISOTOPES