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Title: Primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide

Abstract

A pulmonary fibrosarcoma of bronchial origin was discovered in a Rhesus monkey that died of pulmonary fibrosis 9 years after inhalation of plutonium-239 dioxide and with a radiation dose to lung of 1400 rad (14 Gy). It grew around the major bronchus of the right cardiac lung lobe and extended into the bronchial lumen and into surrounding pulmonary parenchyma. It also readily invaded muscular pulmonary arteries, resulting in infarction and scarring in the right cardiac lobe. Despite this aggressive growth, the tumor did not metastasize. The primary cause of death was severe pulmonary fibrosis involving the alveolar septa and and perivascular and peribronchial interstitium. Bullous or pericitrical emphysema was prominent. The initial lung burden of plutonium in this monkey was 270 nCi (10 kBq) which is equivalent to approximately 500 times the maximum permissible lung burden for man on a radioactivity per unit body weight basis. The time-dose relationship for survival is consistent with that of dogs and baboons that inhaled plutonium dioxide and died with lung tumors.

Authors:
; ;
Publication Date:
Research Org.:
Lovelace Inhalation Toxicology Research Institute, Albuquerque, NM
OSTI Identifier:
5719536
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiat. Res.; (United States); Journal Volume: 112:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FIBROSARCOMAS; RADIOINDUCTION; LUNGS; RADIATION DOSES; PLUTONIUM 239; CARCINOGENESIS; FIBROSIS; INHALATION; MAXIMUM PERMISSIBLE DOSE; MONKEYS; PLUTONIUM DIOXIDE; ACTINIDE COMPOUNDS; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMALS; BODY; CHALCOGENIDES; DISEASES; DOSES; EVEN-ODD NUCLEI; HEAVY NUCLEI; INTAKE; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; ORGANS; OXIDES; OXYGEN COMPOUNDS; PATHOGENESIS; PATHOLOGICAL CHANGES; PLUTONIUM COMPOUNDS; PLUTONIUM ISOTOPES; PLUTONIUM OXIDES; PRIMATES; RADIOISOTOPES; RESPIRATORY SYSTEM; SAFETY STANDARDS; SARCOMAS; STANDARDS; TRANSURANIUM COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells

Citation Formats

Hahn, F.F., Brooks, A.L., and Mewhinney, J.A. Primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide. United States: N. p., 1987. Web. doi:10.2307/3577266.
Hahn, F.F., Brooks, A.L., & Mewhinney, J.A. Primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide. United States. doi:10.2307/3577266.
Hahn, F.F., Brooks, A.L., and Mewhinney, J.A. Sun . "Primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide". United States. doi:10.2307/3577266.
@article{osti_5719536,
title = {Primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide},
author = {Hahn, F.F. and Brooks, A.L. and Mewhinney, J.A.},
abstractNote = {A pulmonary fibrosarcoma of bronchial origin was discovered in a Rhesus monkey that died of pulmonary fibrosis 9 years after inhalation of plutonium-239 dioxide and with a radiation dose to lung of 1400 rad (14 Gy). It grew around the major bronchus of the right cardiac lung lobe and extended into the bronchial lumen and into surrounding pulmonary parenchyma. It also readily invaded muscular pulmonary arteries, resulting in infarction and scarring in the right cardiac lobe. Despite this aggressive growth, the tumor did not metastasize. The primary cause of death was severe pulmonary fibrosis involving the alveolar septa and and perivascular and peribronchial interstitium. Bullous or pericitrical emphysema was prominent. The initial lung burden of plutonium in this monkey was 270 nCi (10 kBq) which is equivalent to approximately 500 times the maximum permissible lung burden for man on a radioactivity per unit body weight basis. The time-dose relationship for survival is consistent with that of dogs and baboons that inhaled plutonium dioxide and died with lung tumors.},
doi = {10.2307/3577266},
journal = {Radiat. Res.; (United States)},
number = ,
volume = 112:2,
place = {United States},
year = {Sun Nov 01 00:00:00 EST 1987},
month = {Sun Nov 01 00:00:00 EST 1987}
}